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New Baldness Treatment Being Developed by Scientists


Scientists Have Developed a Baldness Treatment That Helps Grow New Follicles


The market is packed with all sorts of treatments for baldness, but now scientists believe they have come up with the most effective one yet - and it's in the form of an ointment.  It seems a little far fetched, but South Korean scientists claim it doesn't only stop hair loss, but also promotes hair regrowth, after testing the formula on hairless mice.

Professor Choi Kang-yeol of Yonsei University, and a team of researchers discovered a protein responsible for hair loss in androgenetic alopecia, also known as pattern baldness - the most common type of hair loss in both men and women.

"We have found a protein that controls the hair growth and developed a new substance that promotes hair regeneration by controlling the function of the protein," Kang-yeol said.

"We expect that the newly developed substance will contribute to the development of a drug that not only treats hair loss but also regenerate damaged skin tissues."

CXXC-type zinc finger protein 5 (CXXC5), which acts as a negative regulator on the Wnt/β-catenin pathway, is linked to hair regeneration and wound healing.  When binded with a protein called the Dishevelled protein, it prevents hair cell development and functioning.  The team have developed a bind called PTD-DBM, and when applied to the bare skin of bald mice for 28 days, new follicles started to develop. 


 

A paper from 2013 found that, in humans, a treatment for common types of baldness was more effective when accompanied by microneedling - rolling very fine needles over the skin to puncture it. This theory has been backed by many hair loss sufferers who claim that skin puncturing devices like the derma roller, can indeed promote hair regrowth.  The wounds from puncturing can stimulate the generation of hair follicles, thus promoting hair growth.

A 2015 study showed promise for using stem cells to promote the growth of follicles, but realistically, we should not expect a complex treatment of this nature to hit the market any time soon. We should also expect an even longer wait for it to be medically approved as a treatment for baldness. 

despite this, the whole study looks positive, and we should certainly have reason to be optimistic about this development. There are currently testing phases happening on animals to determine whether it's toxic, before proceeding to human trials.

Their research has been published in the Journal of Investigative Dermatology.

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