<title>Hair Loss Review Centre

What Happened To Provillus Hair Loss Treatment?

What happened to Provillus, and is it still available to buy?

During its time, the hair loss treatment brand, Provillus, was one of the most heavily marketed hair products on the market. The brand's star product was its supplement (one for men and another for women), but it also had a topical solution.

From the late-2000s to around 2015, Provillus, along with fellow American brand, Procerin, was the market-leading hair supplement to treat hair loss. It could be said that these two brands, in particular, were the pioneering hair growth supplements.

Procerin is still active, however, Provillus is no longer available on the market. So, we ask; what is the reason for the decline of Provillus? How could what was once a market leader, decline so quickly?

What is Provillus?

Provillus was a naturally formulated hair supplement that contained ingredients that could help promote a healthy scalp and head of hair. The theory behind Provillus was to revive the hair follicles with growth stimulators and attack hair loss at its source by blocking DHT.

Its key ingredients were Vitamin B6, Zinc, cucurbita maxima, and nettle root. This supplement was not FDA approved, but it did act as a safe alternative to harsh prescription drugs such as finasteride. The formulation was very similar to Procerin.

Why is Provillus no longer available on the market?

Hair Loss Review Centre contributor, and hair loss specialist for ten years, David Griffiths, gives us his view of why Provillus is no more:

Provillus was founded in 2002, which is before any other hair supplement of its kind. Its closest competitor, Procerin, was founded just a year later in 2003. These two supplements, at the time, were absolute giants, mainly because they both had no competition. By the late 2000s, Provillus, and Procerin, were the go-to non-prescription supplements for treating hair loss.

Things started to change as we entered the 2010s with the emergence of TRX2 in 2011, and various other brands such as Viviscal. These higher-end supplements became hugely popular at the time, and by 2015, there were more additions to the market, with popular supplements like HR23+ and Nutrafol on the scene.

As we entered the third decade, the hair supplement market became hugely saturated, which meant less and less people were buying Provillus. Also, the standard and effectiveness of hair supplements became better, over time, which left supplements like Provillus rather outdated.

There are endless amounts of hair supplements on the market, with some being more effective than others. As things currently stand, Provillus would rank in the mid-range of hair supplements for effectiveness.

So, with stronger competition, and more effective supplements out there, it was only a matter of time until Provillus succumbed to the pressure. And although Provillus has had its time, its legacy cannot be denied. It was the first of its kind, playing a significant role in the rise of hair supplements.

What is the best hair supplement now?

The best and most effective hair supplement on the market is HR23+ (founded in 2015). What makes HR23+ stand out from the rest is the way it has constantly evolved its formula, in order to move with the times, and keep its effectiveness, as well as improve it.

HR23+ has evolved its formula twice, sine its release in 2015. Once in 2018, and then again in 2022.

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What Season is Hair the Thinnest, and Thickest?

What Season Does Hair Become Thinner?

Question from Beatrice Clover.

What time of the year is the hair at its thinnest, and thickest?

Answer:

Our hair's thickness is dependent on a number of factors, but the main cause is seasonal hair loss. Seasonal hair loss dictates the thickness of the hair throughout different seasons.

Autumn is, by far, the most common season for hair shedding. This is the time of year when the hair is thinner than usual. Winter tends to be the best hair growth season, and that is when our strands are thicker than normal.

One study has shown that many of us tend to shed excessively during September, as we head into autumn season. We also experience a lighter shedding phase around April time (early spring).

This can differ from person-to-person, but generally speaking, our hair is at its thinnest during early autumn and early spring. The hair tends to thrive at its thickest during the peak winter months, and early in summer time.

If you are experiencing severe cases of seasonal hair loss, then be sure to adjust your hair care plan according to the different seasons. Ease up on harsh chemical based products and heat based styling devices during the shedding seasons. Instead, opt for natural hair products.

For more information on seasonal hair loss, you may want to read:

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How To Stop Hair Loss: Here Are Your Options

Most men (65 percent) and women (50 percent) experience some form of hair loss by the age of 40. Some cases are more severe than others, but either way, hair loss is a common issue, and it’s not about to go away any time soon.

The problem is, as things stand, there is not a cure for permanent hair loss types like pattern baldness, for example. However, there are treatments that can help slow down and even halt the formation of hair loss, and support the function of healthy hair growth.

Common Hair Loss Types

But before we look into the treatments available, let’s first look at what the more common hair loss types are in both men and women.

Androgenic Alopecia

Androgenic alopecia, also called pattern baldness, is the most common and well known permanent type of hair loss in men (male pattern baldness), but it can also affect women (female pattern baldness).

Pattern baldness is heredity, and the condition worsens with ageing. Although this hair loss type cannot be cured, medications like finasteride (for men only) and minoxidil can help stump further hair fall, and in some rare cases, potentially regrow some of the lost hair.

However, many people choose to avoid such treatments as they can give negative side-effects.

Seasonal Hair Loss

Seasonal hair loss is a lot more common than many think. Much like seasonal allergies, seasonal hair shedding occurs when a change in temperature puts stress on the scalp and follicles, which leads to strands falling out.

Seasonal hair loss usually occurs during certain periods of the year whereby some people experience a radical increase in hair shedding, most commonly in the autumn months.

With time, shedding should stabilise back to normal daily levels and normal hair growth will continue, but the reoccurrence of condition makes it an issue that should be treated.

Menopausal Hair Loss

After women go through menopause, some physical symptoms can appear, including excessive hair thinning. Fortunately, unlike genetic hair loss, most hair thinning caused by hormonal imbalances can be treated and reversed.

The majority of women will experience menopausal hair loss, however, not all thinning is caused by this. Growing older also plays a key role in hair loss.

Postpartum Hair Loss

Many women suffer from hair loss post-pregnancy, and although it can be emotionally challenging to deal with, it should be noted that this kind of hair loss is common during the postpartum period and is usually temporary.

As the effects of pregnancy-related hormonal changes on your body slowly subside, your hair will usually return to normal, but some women experience further thinning, which means certain treatments would be required.

Telogen Effluvium

In telogen effluvium, which is a stress-related hair loss condition, significant stress pushes large numbers of hair follicles into a ‘resting phase’. Within a short space of time, the affected hairs might fall out suddenly.

Hair that is lost as a result of stress or anxiety, will usually start to grow back once the stress levels are back to normal. Stress-related hair loss can usually be countered with rest, meditation, and a healthy lifestyle.

There are many more hair loss types, but the ones mentioned above are the most common in men and/or women.

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Treatments for Hair Loss

Now that we have established what the most common types of hair loss are, let us delve into what treatments are available for hair loss in both men and women.

Finasteride

Finasteride, often branded as Propecia, or Proscar, is a medically approved prescription drug for male pattern baldness. This oral pill has shown to be effective is slowing down, and even halting hair loss in men, however, it can come with negative, long-term side-effects, such as erectile dysfunction, impotence, lowered libido, skin rash, increase in breast size, breast tenderness, feminisation, depression and anxiety.

Finasteride has to be taken long-term, or the hair will continue to fall out the moment the user stops taking it.

Cost: Inexpensive.
Effectiveness: Good.
Cons: Potential negative side-effects and it needs to be used long term.

Minoxidil

Minoxidil, most commonly known as Regaine/Rogaine, is the only medically approved topical hair loss treatment. Minoxidil comes in two solutions, 5% for men, and 2% for women, respectively.

With continued use, minoxidil can help slow down the rate of hair fall and help regrow hair, albeit on a small scale. However, like finasteride (although, not as severe), minoxidil can come with negative side-effects, with the most common being an itchy scalp, dizziness, headaches, skin rash, and even weight gain.

Cost: Inexpensive.
Effectiveness: Average.
Cons: Potential negative side-effects and it needs to be used long term.

Ketoconazole

There has been some research that suggests ketoconazole may help to treat hair loss caused by pattern baldness. Researchers believe that ketoconazole may do this by affecting DHT, the hormone responsible for hair loss in men.

Ketoconazole is most commonly used in shampoo/topical form, with Nizoral being the go-to brand. Again, much like with minoxidil, ketoconazole’s effects are minimal, but it can be effective when used in conjunction with other hair loss treatments.

Cost: Inexpensive.
Effectiveness: Average.
Cons: Not effective on its own.

Hair Supplements

Multivitamin hair supplements do not get the full credit they deserve, but the reality is, they can be an excellent treatment for early stages of hair loss in men and women.

A good multivitamin hair supplement, like HR23+, can go a long way in encouraging hair growth, because it contains a range of key ingredients that benefits the hair.

Multivitamin hair supplements are also a safe and natural alternative to the harsh prescription drugs, which means you can treat hair loss without ever needing to compromise on your health.

Cost: Inexpensive.
Effectiveness: Good.
Cons: Needs to be used long term.

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Keratinocyte Growth Factor

Keratinocyte growth factor (KGF) is an active ingredient that may help promote hair growth. KGF utilises the nutrients that contain prebiotics, polysaccharides and antioxidants to protect the cells that make hair. With continued application, KGF can help prevent hair loss and encourage the healthy function of hair growth.

The most common form of KGF is in a topical solution, like a serum, with a recommended application of around 4–5 times per week, long term.

Cost: Inexpensive.
Effectiveness: Average.
Cons: Needs to be used long term.

Micro Needling

Most commonly done as an anti-aging skin treatment, micro needling has also shown to be an effective method of treatment for hair loss. Micro needling is a process of making wounds in the skin, which is thought to regenerate the health of the hair follicles by the creation of protein and collagen during the skin’s recovery phase.

With continued use of micro needling devices, such as derma rollers and derma stamps, hair loss can be prevented, and hair regrowth can also occur.

Cost: Inexpensive.
Effectiveness: Good.
Negatives: Needs to be used long term.

Platelet Rich Plasma

Platelet Rich Plasma (PRP) is a process whereby some bloody is extracted from one part of the body, and then transferred/injected into the scalp area, in order to increase bloody flow in the scalp.

Although some doctors use PRP to encourage the growth of thinning hair and promote the growth of transplanted hair, it is not yet a proven hair loss treatment, and more tests are needed to establish exactly how effective this therapy is.

Cost: Expensive.
Effectiveness: Relatively unknown.
Cons: Not enough evidence to suggest it is effective for its high price.

Hair Laser Growth Therapy

According to various studies, hair laser growth therapy treatment appeared to be safe and effective for hair growth in both men and women. Hair laser growth therapy treatment has shown to increase the rate of hair growth in over 30% of men and women, however, the results are minimal.

Hair laser growth therapy treatment sessions can be done at professional hair clinics, or alternatively, the process can be done at home, with purchased devices like hair laser combs and brushes.

Cost: Expensive.
Effectiveness: Average.
Cons: Not effective enough for its high price.

Hair Transplantation

For more severe stages of baldness, hair transplantation can be a good option. Hair transplantation surgery is a process whereby the follicles from the donar area are extracted and then reinserted into the bald areas of the scalp.

Hair transplantations can be very effective, however, in most cases, the patient will have to have a number of transplants over time. A good hair transplant is not a guarantee, as many factors play a key role in this, such as the patient’s donar area, their stage of hair loss, and their hair loss type.

Cost: Expensive.
Effectiveness: Varies from person-to-person.
Cons: The procedure is expensive, and does not guarantee successful results.

Conclusion

There is no cure for baldness, however, science has come a long way in recent years, and now there are a wide range of viable treatments that can help slow down and even stop hair loss in both men and women.

It should be noted that the earlier hair loss is treated, the more chance there will be of maintaining healthy hair for a longer period of time. More advances stages of hair loss will often require more expensive, surgical procedures, therefore it is important to tackle the issue as early as possible.

Whether hair loss is treated with prescription drugs, safer alternatives, or surgical procedures, results will always vary from person-to-person. So, until there is a cure for hair loss, treating it will always be an unpredictable process.

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Cover Hair Loss with Hair Building Fibres

Conceal your patchy scalp with hair building fibres

If you are losing your hair, and started to notice bald patches and recession at the hairline, then hair building fibres could be just the solution that you are looking for.

Hair building fibres, or hair fibres, are fast becoming a popular solution for men (and women) who are looking to conceal hair loss, without the costs and health risks of using harsh medications.

What Are Hair Building Fibers?

Hair building fibres are small fibres that attach to your existing strands of hair, creating the appearance of extra density. They're applied directly to your hair, usually with a hold-on spray applicator, and come in a variety of shades to match your natural hair type and hair colour.

The fibres help conceal the bald and thinning patches of the scalp, as well as add the illusion thickness and density to the hair.

Using hair fibres is the most effective and natural way to correct baldness and thinning hair, and the end results can be mightily impressive. An increasing amount of people are turning to hair fibres because it's a quick and easy way to cover thinning hair.

What are the best Hair Building Fibres?

There are many hair building fibre brands to choose from. There is very little difference from brand-to-brand. It really is a case of using the one that you are most comfortable with. Some brands may work for your hair type better than others, but generally speaking, any brand should be fine.

Some of the most well known hair building fibre brands include; Toppik, Bosley, Caboki, Febron, Miracle Mane, and HairMaker.

How to use Hair Building Fibres?

Hair fibres are very easy to use. After showering and drying your hair, simply apply the fibres evenly to the thinning areas of your scalp, and then apply the hold-on spray. The fibres are generally considered to be waterproof and windproof. They should stay in the hair for up to 48 hours.

What are the disadvantages of hair fibres?

Hair fibres have many disadvantages, such as they can fall off at touch, and you may not feel them like natural hair. Most hair fibres contain synthetic keratin, which does not work well with most scalps. Synthetic hair fibres can be messy and impractical.

With that said, hair building fibres are completely non-toxic, and 100% safe to use, which means you can go about your day without suffering from any risks or side-effects.

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Oral Minoxidil Tablets - Are They Effective for Treating Baldness?

Are Oral Minoxidil Tablets Effective for Treating Baldness?

Many of you will be familiar with the medically approved topical hair loss treatment, minoxidil, or as it is more commonly known under the brand name Regaine (Rogaine in the USA).

Minoxidil has been FDA-approved as a hair loss treatment since 1988, and is still the only topical medication for baldness and thinning hair in both men (5% solution) and women (2% solution).

Interestingly, the drug was never originally designed for scalp application, and nor was it meant to be for treating hair loss. Minoxidil was initially developed to treat high blood pressure.

In 1979, the FDA approved a minoxidil-based drug by Pfizer, called Loniten, to treat blood pressure. It was then shown how well minoxidil could grow hair, albeit on a limited scale. Further trials were done for minoxidil and its effects for hair growth, and that's when the topical solution called Regaine/Rogaine was formed, as a foam or liquid.

Fast forward to 2022, and dermatologists are still using minoxidil to treat hair-loss, but differently - this time, through an oral pill. The same pill that doctors prescribe at a higher concentration to treat hypertension can work just as effectively as the topical solution, and what's more, it's cheaper, too.

Like Regaine/Rogaine (or any other hair loss treatment on the market, for that matter), oral minoxidil doesn't work for everybody, but it's a good alternative to the topical formulation of the medicine, which can be a hassle to apply, and leave the hair looking and feeling greasy.

Like with any drug, the oral minoxidil pill does come with the risk of some potential side-effects. Some side-effects may include; Temporary shedding, ankle swelling and fluid retention, low blood pressure and feeling lightheaded, fast heart rate, and headaches.

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Has David Beckham Had a Hair Transplant?

He's one of the most famous faces in the world, with millions to his name, and he's a global sporting icon in status. But, not only that, former Manchester United and England footballer, David Beckham, has a history of having great hair!

The Beckham brand has grossed millions since his rise to fame in the late 1990s, and much of that has been down to Beckham's style and image. David's hair has also played a big part in his success.

However, in recent times, many people have questioned whether David Beckham has had work done on his locks, as he was evidently thinning in his 30s, only to have much thicker looking strands by the time he reached his 40s. The obvious assumption would be that he's had a hair transplant.

So, let's take a look through the years of Beckham's hair, and try to establish whether he has indeed had a hair transplant, or not...

If we look back to 2000, we see a young David Beckham, which gives us a clear view of what his original hairline was. As you can see from the image (above) that his hairline, like most guys in their 20s, was full, and low down on his forehead. At this stage, there was no evidence of thinning or hairline recession.

Fast forward ten years, and we can see a maturing of the hairline. This is very normal for men to go through when they reach their 30s. We usually see slight recession at the front of the hairline, only by a few centimetres. At this stage, David still had a good head of hair, and a strong hairline, although, very early stages of thinning were noticeable.

By 2015, Beckham's hairline looked to have receded quite a bit. This was the year that David turned 40, which is a very common time for men to start really losing their hair. As you can see from the image (above), David's hairline receded a couple of inches since 2010, and it was clear that Becks was indeed experiencing early stages of male pattern baldness (Norwood Hamilton II-III).

As you can see from this image (above), David Beckham's hairline was very much restored. The hairline, and overall density of his hair, looked thicker, and filled-in. It is absolutely clear that Becks had undergone hair transplantation surgery, in order to restore his hairline, and hair density.

As you can see from this recent photo, David Beckham's hairline looks to have been fully filled in, with far more density that it was in 2015. It would be safe to say that this is due to a hair transplant. Although the hairline has been restored, you can tell that it does not look natural.

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Microneedle Patches That Restore Hair in Balding Mice Using AI

China backed researchers find a way to restore hair with a microneedle patch

Hair loss affects about two thirds of men, and around half of women, by the age of 40. There isn't a cure for hair loss, but there are treatments available that can assist in the prevention of hair fall, and the maintenance of hair growth.

Most hair loss sufferers dream of hair regrowth, and now, according to some new research, this could be made possible after some promising trials.

Researchers reporting in ACS' Nano Letters have used artificial intelligence (AI) to predict compounds that could neutralise baldness-causing reactive oxygen species in the scalp.

Using the best candidate, they constructed a proof-of-concept microneedle patch and effectively regenerated hair on mice.

The majority of people who suffer with hair loss have a condition called androgenic alopecia, or more commonly known as pattern baldness. This is a condition whereby hair follicles can be damaged by androgens, inflammation or an overabundance of reactive oxygen species, such as oxygen free radicals.

When the levels of oxygen free radicals are too high, they can overwhelm the body's antioxidant enzymes that typically keep them in check. Superoxide dismutase (SOD) is one of these enzymes, and researchers have recently created SOD mimics called "nanozymes."

But so far, those this has not proved to be effective at removing oxygen free radicals. So, Lina Wang, Zhiling Zhu and colleagues wanted to see whether machine learning, a form of AI, could help them design a better nanozyme for treating hair loss.

Choosing transition-metal thiophosphate compounds as potential nanozyme candidates, the researchers proceeded with the study. They tested machine-learning models with 91 different transition-metal, phosphate and sulfate combinations, and the techniques predicted that MnPS3 would have the most powerful SOD-like ability.

Next, MnPS3 nanosheets were synthesized through chemical vapor transport of manganese, red phosphorus and sulfur powders. In initial tests with human skin fibroblast cells, the nanosheets significantly reduced the levels of reactive oxygen species without causing harm.

Based on these results, the team prepared MnPS3 microneedle patches and treated androgenic alopecia-affected mouse models with them. Within 13 days, the animals regenerated thicker hair strands that more densely covered their previously bald backsides than mice treated with testosterone or minoxidil.

The researchers say that their study both produced a nanozyme treatment for regenerating hair, and indicated the potential for computer-based methods for use in the design of future nanozyme therapeutics.

Sourced from: https://www.sciencedaily.com/releases/2022/10/221031104454.htm

Materials provided by American Chemical Society. Note: Content may be edited for style and length.

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