Platelet-Rich Fibrin (PRF) for Hair Growth

Platelet-rich fibrin (PRF) hair growth treatment

What is Platelet-rich fibrin (PRF) and does it treat hair loss?

Platelet-rich fibrin (PRF) is a biological treatment derived from a patient's own blood that contains a high concentration of platelets, growth factors, and other bioactive proteins. PRF is commonly used in various medical and cosmetic procedures, including hair restoration and regrowth. 

While it has gained popularity as a potential treatment for hair loss, it's essential to understand that the scientific evidence supporting its effectiveness is still limited, and results may vary from person to person.

Here's how PRF is typically used for hair growth:

Blood Collection: A small amount of your blood is drawn, usually from your arm, similar to a regular blood draw.

Centrifugation: The collected blood is then placed in a centrifuge, which spins the blood at high speeds to separate its components. This process separates the red blood cells, platelet-rich plasma (PRP), and platelet-poor plasma.

Extraction of PRF: The PRF is then separated from the PRP and platelet-poor plasma. PRF is a fibrin matrix that contains a higher concentration of platelets and growth factors compared to PRP.

Application: The PRF is then injected into the scalp in the areas where hair growth is desired. It can also be applied topically in conjunction with micro needling.

The idea behind using PRF for hair growth is that the growth factors and other bioactive substances in the PRF can stimulate hair follicles, promote circulation, and potentially encourage hair regrowth in areas affected by hair loss or thinning.

However, it's important to note the following considerations:

Limited Scientific Evidence: While some small studies and anecdotal reports suggest that PRF may have a positive impact on hair growth, more robust clinical research is needed to establish its effectiveness and safety conclusively.

Variability in Results: The effectiveness of PRF for hair growth can vary from person to person. Factors such as the cause of hair loss, the extent of hair loss, and an individual's overall health can all influence the outcomes.

Not a Permanent Solution: PRF treatment typically requires multiple sessions, and its effects are not permanent. Maintenance treatments may be necessary to sustain the results over time.

Consultation with a Specialist: Before considering PRF for hair growth, it's essential to consult with a qualified healthcare provider or dermatologist who can assess your specific situation and provide guidance on the most suitable treatment options.

What's the difference between PRF and PRP?

Platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) are both derived from a patient's blood and contain a high concentration of platelets and growth factors, but they differ in their preparation methods and composition. 

Here are the key differences between PRF and PRP:

Preparation Method: 
  • PRP is prepared by taking a small sample of the patient's blood and then spinning it in a centrifuge to separate its components. This process separates the blood into its constituent parts: red blood cells, platelet-poor plasma, and platelet-rich plasma. The platelet-rich plasma is the part used for various treatments.
  • PRF is also prepared from a patient's blood, but it is processed differently. After blood collection, it is centrifuged at a lower speed compared to PRP. This lower speed allows PRF to have a different composition, with a fibrin matrix that holds the platelets and growth factors within it.

  • PRP primarily contains a higher concentration of platelets and growth factors compared to whole blood. It is a liquid component without the fibrin matrix found in PRF. 
  • PRF contains platelets and growth factors as well, but it also includes a fibrin matrix, which is a natural component of blood involved in wound healing and tissue repair. The presence of this fibrin matrix in PRF is believed to enhance its regenerative potential.

Release of Growth Factors:

  • When PRP is injected into the treatment area, the growth factors and platelets are released immediately. This results in a rapid burst of growth factors at the site of application.
  • In PRF, the fibrin matrix acts as a scaffold that slowly releases growth factors over a more extended period. This sustained release of growth factors is thought to provide longer-term benefits.
Texture and Application:
  • PRP is a liquid and is typically injected directly into the target area. It is commonly used for a wide range of medical and cosmetic procedures.
  • PRF has a thicker, gel-like consistency due to its fibrin matrix. It can be injected into the target area, used topically in conjunction with micro needling, or even placed in surgical sites during certain procedures.

In summary, both PRP and PRF are derived from a patient's blood and contain platelets and growth factors, but PRF includes a fibrin matrix, which may lead to differences in how growth factors are released and utilized. 

The choice between PRP and PRF may depend on the specific medical or cosmetic procedure, the desired treatment outcomes, and the preferences of the healthcare provider or patient.


While PRF is an intriguing option for hair growth, it should be approached with caution. It's advisable to discuss your concerns and treatment options with a healthcare professional who can provide a personalised recommendation based on your unique needs and circumstances. 

Additionally, keep in mind that ongoing research in the field of hair restoration may yield more effective and evidence-based treatments in the future.

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